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POPSInfectious diseases caused by pathogenic microorganisms An infectious disease is a clinically evident disease resulting from the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. These pathogens are able to cause disease in animals and/or plants.
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POPSHow to fold Proteins Proteins are complex molecules, and understanding the way they can fold using distributed computing, in the unused cpu load of home computers, can spread the load and research in more detail , both the way proteins fold, and the effects of incorrect folding. A prime example of such an instance in in the proteins known as prions, which with a wrong fold can be one of the contributing factors in Alzheimer's disease. The foldingathome network is the biggest computer in the world, with calculations done by the petaflop
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POPSHow to BBQ a Healthier Burger While marinades are best because they cover the whole surface, simply shaking on dried herbs may reap the same health benefits. "Barbeque sauces seem to work too," Smith added. Just make sure you shake or smear on spices before you get to the grill. Once the cooking process begins, the HCAs are there to stay
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POPSGovernment asks court to block wider testing for mad cow Bush administration on Friday urged a federal appeals court to stop meatpackers from testing all their animals for mad cow disease, but a skeptical judge questioned whether the government has that authority.Other variations of Prions Diseases include Kuru, Alzhiemer's disease, Parkinson's disease, Huntington's disease, BSE,Bovine Spongiform Encephalopathy, CJD,Creutzfeldt Jakob's Disease, Alpers disease, Fatal Familial Insomnia, Scrapies Sheep Disease, TSE,Transmissible Spongiform Encephalopathies, CWD Chronic Wasting Disease, Transmissible mink encephalopathy, Feline spongiform encephalopathy, Ungulate spongiform encephalopathy,
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POPSColony Collapse Disorder Mapping comparing CCD mapping to CWD mapping we see some similarity, remembering prions live on in water and soil for several years, can prions be to blame for Mad Bees Disease? Bees harvest essential amino acids of proteins.
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POPSMapping CWD in North America concentration of CWD , prions live on in soil and water for several years, comparing to Colony Collapse Disorder mapping, can bees be infected with prions?
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POPSPrioNet Canada: prion network join in PrioNet Canada is a Network of Centres of Excellence for research on Bovine Spongiform Encephalopathy, commonly known as mad cow disease, and other Transmissible Spongiform Encephalopathies or prion diseases. The PrioNet Canada web site was built to serve as a portal for members and non-members alike, to access the latest findings in prion science and to discover the wealth of possibilities provided by the network concept. Prion Video Watch a short video on prions produced by the Alberta Prion Research Institute. PrioNews Read the Jan-March 2007 issue of PrioNet's newsletter. Mad Cow Mysteries Science journalist Jay Ingram is hosting a four-city prion public lecture series this month. Register now in your city! High Impact Fund PrioNet Canada establishes fund to support research urgencies in real-time BSE/TSE events.
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POPSSmall regions within prion proteins regulate their ability to cross species barriers
PRINCIPAL INVESTIGATOR Susan Lindquist, Whitehead Institute http://www.wi.mit.edu/research/faculty/lindquist.html Written by David Cameron Susan Lindquist’s primary affiliation is with Whitehead Institute of Biomedical Research, where her laboratory is located and all her research is conducted. She also is a professor of biology at Massachusetts Institute of Technology and a Howard Hughes Medical Institute investigator. "Prion recognition elements govern nucleation, strain specificity and species barriers" Peter M. Tessier (1) & Susan Lindquist (2) (1) Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. (2) Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. Advance online publication at www.nature.com at 1 pm U.S. Eastern time, May 9, 2007. Advance online publication digital object identifier: 10.1038/nature05848. This resea
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POPSScientists Identify Prion's Infectious Secret But prions have another characteristic that enables them to wreak havoc. They recruit other, properly folded proteins into misforming along with them, a process Lindquist calls a "conformational cascade." In many organisms, this conformational cascade creates long fibers called amyloids. (The brains of animals that have died from prion infections are literally packed with amyloid clumps.)
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POPSBSE CASE CONFIRMED IN BC More recently (April 2007) was found that; Alzheimer's disease, Parkinson's disease, type II diabetes, the human version of mad cow disease and other degenerative diseases are more closely related at the molecular level. An international team of chemists and molecular biologists reported; „A mystery on which the new Nature paper sheds light is what causes different strains of prions (infectious proteins) in which the protein sequence is identical. Our research gives a strong hypothesis that the origin of prion strains is encoded in the packing of the molecules in the fibrils which we are seeing in the crystals…“
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POPSNews-Medical.Net 'Understanding how rogue prions kill cells is crucial to learning more about the prion diseases that remain a major concern for public and animal health following the BSE epidemic in UK cattle and the emergence of its human counterpart variant CJD. This work forms part of a major research strategy at the MRC Prion Unit to translate basic research findings into potential treatments in the years ahead. The underlying mechanism by which rogue prion proteins disrupt the UPS may be of wider relevance in understanding how misshaped proteins cause other disorders too, like Alzheimer's disease.''
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