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POPSNeurogenesis and Brain Plasticity in Adult Brains Elkhonon Goldberg, neuroscientist and co-founder of SharpBrains, discussing Brain Plasticity and Cognitive Fitness, pointed out that “as we age, our expert knowledge remains strong, and our capacity for solving problems within our areas of expertise can often exceed that of those who are younger.” He further employed us to “turn neuroplasticity to your advantage” by: • welcoming novel challenges • beware of being on mental autopilot • remain cognitively active
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POPSEnding Moderate Drinking Tied To Depression The mice were tested for depression-like behavior using a widely recognized method called the Porsolt Swim Test. The mice are placed inside a beaker filled with water and allowed to swim for six minutes. Mice are good swimmers and have no problem completing this task. The amount of time they spend immobile (floating and not swimming) is measured as an index of despair or depression-like behavior. The more time a mouse spends immobile, the more "depressed" it is thought to be. "This research provides the first evidence that long-term abstinence from moderate alcohol drinking -- rather than drinking per se -- leads to a negative mood state, depression," Hodge said.
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POPSSchizophrenia: The Curse That's Almost a Blessing
A recent study may have found what kind of process goes awry in schizophrenic brains. Researchers found that DISC1 regulates the migration of new neurons in the adult brain. When the levels of DISC1 were reduced in mice during adult neurogenesis, the newborn neurons sped up and overshot their intended targets within the hippocampus, When the neurons finally reached their destinations, they forged an unusual number of connections with neighboring cells, a series of events that might give rise to the abnormal—and quite crippling—brain functions associated with schizophrenia, according to Hongjun Song, a Johns Hopkins neurologist who also worked on the study. It is possible, Song says, that further research will lead to a drug that treats schizophrenia by restoring normal neurogenesis. So what evolutionary advantage could schizophrenia-related genes bring to people who have some of the genes but not the disease? For now, this remains one of the many open questions.
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