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POPSToothbrush Sanitizer Uses Natural Dry Heat Works Safely The Germ Guardian Toothbrush Sanitizer effectively kills germs in 45 minutes. This is done by dry heat, which is a safe, natural way to kill germs on toothbrush bristles without the use of chemicals. The toothbrush sanitizer kills germs that cause: colds, flu and more. While sanitizing it won't damage plastic toothbrushes or electronic toothbrush heads.