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POPSWere 1918 pandemic deaths due to aspirin overdose? More: Some doubts were raised even at the time. At least one contemporary pathologist working for the Public Health Service thought that the amount of lung damage seen during autopsies in early deaths was too little to attribute to viral pneumonia, and that the large amounts of bloody, watery liquid in the lungs must have had some other cause… But of the many factors that might have influenced the outcome in any particular case, Dr. Starko wrote, aspirin overdose stands out for several reasons, including a confluence of historical events… The Journal of the American Medical Association suggested a dose of 1,000 milligrams every three hours, the equivalent of almost 25 standard 325-milligram aspirin tablets in 24 hours. This is about twice the daily dosage generally considered safe today… Doubling the dose given at six-hour intervals can cause a 400 percent increase in the amount of the medicine that remains in the body.
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POPSFDA May Restrict Acetaminophen I don't understand why they cannot "cut" R/X with a benign substance. They say the acetaminophen enhances the pain reliever, but some drugs containing it are not intended for pain. Like some of my colitis medicine.
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POPSFDA Eyes Acetaminophen Liver Risk Three FDA advisory committees will hold a joint meeting on June 29 and 30 to discuss six options to further reduce the risk of liver injury from acetaminophen. Those options are: * Option 1: Reduce current doses or restrict the current maximum adult daily dose, single adult dose, and tablet strength to prescription only. * Option 2: Establish package-size limits for OTC acetaminophen products. * Option 3: Require unit-of-use packaging for prescription acetaminophen products. That means that the products will come to the pharmacy packaged ready for sale, with standardized labeling, instead of in bulk containers. * Option 4: Expand the product warning information on prescription acetaminophen products. For instance, the FDA might require "acetaminophen" to be on the ingredient list, instead of being listed as "APAP," so that consumers can identify that the drug contains acetaminophen. * Option 5: Eliminate combination OTC and/or prescription products tha
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POPSFDA Warns of Deaths from Fenantyl Patch I hadn't heard of opioid patches until I saw this, and while it's not surprising, they don't seem like the kind of thing that should be used without direct medical supervision. There is the variation of the tolerance of people for opiates, the cases where they have been prescribed unnecessarily, and an examples of their strength are cases where there have been suspected overdoses as a result of getting them too hot, or used too often. It seems like the kind of thing that has created an aura of complacency over a drug that has the same significant effect of relief, and/or dependence no matter how it is taken. How many Doctors prescribe things to 'shut people up?'
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POPSPurdue Executives Sentenced Purdue allegedly pushed Oxycontin's label, telling doctors it was less addictive, when it could only claim it might be less addictive.--Matt Herper
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