The densely populated Miami-Fort Lauderdale area in south Florida was not out of the line of fire, and visitors were ordered to flee the vulnerable Florida Keys island chain starting on Saturday.
The storm might then curve into the Gulf of Mexico in the wake of this week's Hurricane Gustav, plowing toward an area that produces a quarter of domestic U.S. oil, and slamming ashore near New Orleans, which was swamped and traumatized by Hurricane Katrina three years ago.
Katrina was a Category 3 when it struck near New Orleans on Aug. 29, 2005, swamping the city and killing 1,500 people on the U.S. Gulf Coast.
"By day four, Ike is forecast to emerge back over open waters in the southeastern Gulf of Mexico," the agency said. "Global models suggest the environment will be favorable for strengthening and the ocean should be plenty warm."