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Here we attempt to review the existing knowledge onthe involvement of ROS in death receptor signaling using TNF-TNFR1as the model system, specifically addressing the involvementof intracellular ROS in TNF-induced cell death and in TNF-inducedactivation of NF-B and JNK and their crosstalk.—Shen,H-M., Pervaiz, S. TNF receptor superfamily-induced cell death:redox-dependent execution.
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