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Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

Nature Reviews Drug Discovery 6, 904 (2007). doi:10.1038/nrd2423

Authors: Russell A. Wilke, Debbie W. Lin, Dan M. Roden, Paul B. Watkins, David Flockhart, Issam Zineh, Kathleen M. Giacomini & Ronald M. Krauss

Serious adverse drug reactions (SADRs) are a major cause of morbidity and mortality worldwide. Some SADRs may be predictable, based upon a drug's pharmacodynamic and pharmacokinetic properties. Many, however, appear to be idiosyncratic. Genetic factors may underlie susceptibility to SADRs and the identification of predisposing

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