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1: J Pharmacol Exp Ther. 2007 Dec 18 [Epub ahead of print]

The effects of COX-2 expression in prostate cancer cells: modulation of response to cytotoxic agents.

LNCaPCOX-2 cells expressed increased levels of survivin and Bcl-2 with enhanced activation of AKT
Celecoxib treatment resulted in highly significant increases in the mRNA expression of the smooth muscle component desmin, the detoxification enzyme GSTpi and Nonsteroidal-Anti-inflammatory response gene NAG-1 in the LNCaPCOX-2 cell line when compared with LNCaPneo cells
Our findings indicate both COX-2 dependent and independent mechanisms attributable to celecoxib and support its utility in the management of prostate cance
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