According to Genesis 6:1-6, the "sons of God" intermarried with "the
daughters of men" and produced offspring that Genesis calls "giants" and "mighty
men of renown." Genesis 6:9 records that Noah was found to be a "just" man and
"perfect in his generations," i.e., untainted by the hybrid genes
introduced into the human bloodline. Genesis 6:12 says that by this time, "all
flesh had corrupted his way upon the earth."
God saved Noah and his family alive and destroyed the hybrid population by
sending the Flood.
When asked by His disciples to outline the signs of His return at the end of
the age, Jesus told them, "And as it was in the days of Noah, so shall it be
also in the days of the Son of man" (Luke 17:26).