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Three rare mutations lower blood pressure
Deepti
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4
4-8-2008 4:07 AM
268 views
tags:
blood pressure
,
genes
,
mutation
,
kidneys
,
salt
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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/9a57ceeb-bd99-43c4-9735-928b321d9c55/F9F47680-E848-4C0E-A605-38F277272933/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.gulfnews.com/world/U.S.A/10203887.html" href="http://www.gulfnews.com/world/U.S.A/10203887.html" style="font-size: 11px;">www.gulfnews.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.gulfnews.com/world/U.S.A/10203887.html">Up to 100 million people globally have genetic mutations that keep their blood pressure low and lower their risk of heart and kidney disease and stroke</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.gulfnews.com/world/U.S.A/10203887.html">findings, published in the journal Nature Genetics, could help scientists design new and better blood pressure drugs. They also shed light on how the kidneys handle salt and in turn regulate blood pressure</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.gulfnews.com/world/U.S.A/10203887.html">People with the mutations, in three genes, have the equivalent of their own, natural, blood-pressure-lowering medication</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.gulfnews.com/world/U.S.A/10203887.html">The researchers homed in on three genes known to cause rare recessive genetic diseases marked by dangerously low blood pressure. All affect how the kidneys handle salt</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.gulfnews.com/world/U.S.A/10203887.html">People with two "bad" copies of the genes, called NCCT, NKCC2 and ROMK, have disease such as Gitelman and Bartter syndromes with extremely low blood pressure. Two of the most commonly used blood pressure medications known as diuretics target the functions of these genes</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;"> </td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/F9F47680-E848-4C0E-A605-38F277272933/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>
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