Human DNA may set off AIDS timebomb


	Human DNA may set off AIDS timebomb

Rashid Malik

12-15-2008 5:00 AM

139 views

tags:

dna, aids

Rashid Malik says:

Link between AIDS and mitochondria found.

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/05ffc862-11a5-4a1b-8611-b63450104f31/F4F629EC-DCFD-4F93-89F2-92B6810D582B/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.newscientist.com/article/mg20026864.800-human-dna-may-set-off-aids-timebomb.html" href="http://www.newscientist.com/article/mg20026864.800-human-dna-may-set-off-aids-timebomb.html" style="font-size: 11px;">www.newscientist.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.newscientist.com/article/mg20026864.800-human-dna-may-set-off-aids-timebomb.html"><P>HOW quickly HIV explodes into AIDS might depend on an individual's DNA. Some variations in the DNA in mitochondria, the parts of cells that generate energy, seem to make AIDS develop twice as fast as others.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.newscientist.com/article/mg20026864.800-human-dna-may-set-off-aids-timebomb.html"><P>By studying the time it took for the subjects to develop AIDS-related diseases and relating it to their genetic information, the team found that some mitochondrial DNA genotypes are associated with rapid development of AIDS. For example, subjects with specific sets of variations known as U5a1 and J haplogroups progressed to AIDS at twice the average rate of the studied population. In contrast, people with the H3 haplogroup progressed more than twice as slowly (<A target="nsarticle" href="http://www.aidsonline.com/pt/re/aids/abstract.00002030-200811300-00003.htm;jsessionid=JwkcJKnwScTj2nzVH1XmNtw5h5TwgXjvv6p5wNsdr5211v5TxLpL!-234910483!181195629!8091!-1"><I>AIDS</I></A>, <A target="nsarticle" href="http://dx.doi.org/10.1097/QAD.0b013e32831940bb">DOI: 10.1097/QAD.0b013e32831940bb</A>).</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.newscientist.com/article/mg20026864.800-human-dna-may-set-off-aids-timebomb.html">This supports existing theories that mitochondria are implicated in the progression of HIV/AIDS. The virus kills immune cells by triggering cell suicide, which appears to happen more easily in cells with mitochondria that generate less energy.</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/F4F629EC-DCFD-4F93-89F2-92B6810D582B/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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