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	Glucose toxicity

davidf1412

6-20-2009 10:20 AM

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/0423d6ee-9fb2-47d5-b108-a233dc2b53c9/EA37F9A9-C82F-445E-8720-4424BED7E175/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://care.diabetesjournals.org/content/26/2/516.full" href="http://care.diabetesjournals.org/content/26/2/516.full" style="font-size: 11px;">care.diabetesjournals.org</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://care.diabetesjournals.org/content/26/2/516.full">These observations lead us into a new paradigm (<A href="#ref-60" class="xref-" id="xref-ref-60-1">60</A>) in which glucose and possibly other macronutrients have a proinflammatory action, while the hormone secreted in response
                  to their intake has an anti-inflammatory effect. This new paradigm facilitates and extends our understanding of normal physiology
                  and pathophysiology and also provides us with novel potential therapeutic uses of insulin and the normalization of plasma
                  glucose concentrations. On the basis of the above discussion, it should be clear that any elevation of plasma glucose concentration
                  is likely to be proinflammatory and thus potentially harmful. Similarly, the administration of insulin is likely to be anti-inflammatory
                  and, thus, may be clinically beneficial. Therefore, when we use insulin to control elevated blood glucose concentrations,
                  we benefit from both the reduction in the toxic effect of glucose and the anti-inflammatory effect of insulin.</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/EA37F9A9-C82F-445E-8720-4424BED7E175/blog/" title="blog or email this clip"><img src="http://content6.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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