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Your Genes Control if Anti Depressants Work
dmegivern
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1-31-2008 1:47 PM
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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/5d48ce4e-e001-4499-932e-9fbcedb715ce/D34908F4-977A-49DE-B97F-B09A7902D959/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html" href="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html" style="font-size: 11px;">psychcentral.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html"><H1 id="post-1832"><A title="Permanent Link: Genes Influence Effectiveness of Antidepressant" rel="bookmark" href="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html">Genes Influence Effectiveness of Antidepressant</A></H1></blockquote><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content8.clipmarks.com/images/clip-icon.gif" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html" href="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html" style="font-size: 11px;">psychcentral.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html"><div align="center"><img src="http://content9.clipmarks.com/blog_cache/psychcentral.com/img/F6F7518D-C887-4E8D-A172-07E72659CA2F" alt="DNA Strand" /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html">A new study discovers subtle genetic variations can influence the efficacy of two widely used antidepressant medications. Researchers found variants in a gene that influences how drugs are absorbed in the brain can compromise the effectiveness of antidepressants citalopram (trade name Celexa) and venlafaxine (Effexor).</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html"><P>“Antidepressants are the first-line treatment for major depression, but their overall clinical efficacy is unsatisfactory, as remission … occurs in only one-third of the patients after a trial with an adequately dosed single drug, and remission rates further decline following successive treatment failures,” wrote the researchers. </P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://psychcentral.com/news/2008/01/24/genes-influence-effectiveness-of-antidepressant/1832.html"><P>“To our knowledge, our results provide for the first time evidence that genetic variants in the [gene for P-gp] account for differences in the clinical efficacy of antidepressants, most likely by influencing their access to the brain,” they wrote.</P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;"> </td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/D34908F4-977A-49DE-B97F-B09A7902D959/blog/" title="blog or email this clip"><img src="http://content6.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>
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