<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/afb24fd3-efb5-4cc0-8b39-54644e3f7c41/C774946C-FD3C-4A3C-A753-071C2F9DB6A8/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/" href="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/" style="font-size: 11px;">consults.blogs.nytimes.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/">I am a neurologist, not a psychiatrist, but I understand that there are clinical situations in which, as a last resort, a procedure known as bilateral cingulotomy can be performed. In this procedure, a small region of the brain is destroyed. I could see that, prior to the destruction of the neural tissue, ZIP might be injected to try to “reset” the synapses in that region. The drug diffuses around 1-2 mm from an injection site in the brain, so the region affected would be restricted.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/">For more general application, we have to develop an activity-dependent form of ZIP, i.e., a drug that becomes active only when the neurons are firing intensely, as when a memory is recalled. This might allow a specific, recalled long-term memory to be erased, rather than all long-term memories. </blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/">How this reconsolidation work fits in with PKMzeta is actively being explored.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/">Developing memory enhancers that convert short- into long-term memories by increasing PKMzeta in the brain is also a possibility. </blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/C774946C-FD3C-4A3C-A753-071C2F9DB6A8/blog/" title="blog or email this clip"><img src="http://content6.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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