<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/5fdbf1c1-7d36-42e2-b8b3-a0a1987c4788/C6102AD1-DCF4-4B79-9B8C-C8B03D9D96D7/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://caonline.amcancersoc.org/cgi/content/full/57/4/225/T4" href="http://caonline.amcancersoc.org/cgi/content/full/57/4/225/T4" style="font-size: 11px;">caonline.amcancersoc.org</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://caonline.amcancersoc.org/cgi/content/full/57/4/225/T4"><P>Potential Therapeutic Approaches to Cancer Cachexia</P><P> <TABLE width="100%" border="1"><TBODY><TR><TD><TABLE width="100%" cellspacing="10" cellpadding="0"><TBODY><TR><TD valign="top" align="left"><HR size="1" noshade="" />Target<BR /><HR size="1" noshade="" /></TD><TD valign="top" align="left"><HR size="1" noshade="" />Examples of Potential Treatments<BR /><HR size="1" noshade="" /></TD></TR><TR><TD colspan="2"><HR /></TD></TR><TR><TD valign="top" align="left" colspan="2">Metabolic pathways<BR /><HR size="1" noshade="" /></TD></TR><TR><TD valign="top" align="left">  Central nervous system</TD><TD valign="top" align="left">Megestrol<SUP>82,83</SUP></TD></TR><TR><TD valign="top" align="left">  Peripheral</TD><TD valign="top" align="left">rGrowth hormone, rGH-RH<SUP>84,85</SUP> Thiazolidinediones<SUP>86</SUP></TD></TR><TR><TD valign="top" align="left" colspan="2">Cytokines<BR /><HR size="1" noshade="" /></TD></TR><TR><TD valign="top" align="left">  General transcription of NF-<IMG border="0" alt="{kappa}" src="http://caonline.amcancersoc.org/math/kappa.gif" />B</TD><TD valign="top" align="left">Small molecules (EPA, curcumin, resvertrol, DHMEQ, sodium salicylate, DHEA)<SUP>86–88</SUP></TD></TR><TR><TD valign="top" align="left">  TNF-<IMG border="0" alt="{alpha}" src="http://caonline.amcancersoc.org/math/alpha.gif" /></TD><TD valign="top" align="left">mAbs (infliximab, adalimumab) Small molecules (etanercept, pentoxifylline)<SUP>89,90</SUP></TD></TR><TR><TD valign="top" align="left">  IL-1</TD><TD valign="top" align="left">rIL-1r antagonist (anakinra)<SUP>91,92</SUP></TD></TR><TR><TD valign="top" align="left">  IL-6</TD><TD valign="top" align="left">mAbs (tocilizumab, CNTO328)<SUP>92,93</SUP></TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></P><P> NF-<IMG border="0" alt="{kappa}" src="http://caonline.amcancersoc.org/math/kappa.gif" />B = nuclear factor <IMG border="0" alt="{kappa}" src="http://caonline.amcancersoc.org/math/kappa.gif" />B.</P><P> TNF-<IMG border="0" alt="{alpha}" src="http://caonline.amcancersoc.org/math/alpha.gif" /> = tumor necrosis factor-<IMG border="0" alt="{alpha}" src="http://caonline.amcancersoc.org/math/alpha.gif" />.</P><P> IL-1 = interleukin-1.</P><P> IL-6 = interleukin-6.</P><P> rGH-RH = recombinant growth hormone-releasing hormone.</P><P> EPA = eicosapentaenoic acid.</P><P> DHMEQ = dehydroxymethylepoxyquinomicin.</P><P> DHEA = dehydroepiandrosterone.</P><P> mAb = monoclonal antibody.</P><P> rIL-1r = recombinant interleukin-1 receptor.</P><P> </P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/C6102AD1-DCF4-4B79-9B8C-C8B03D9D96D7/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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