Study: genetic factor in AIDS - more important than thought

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	Study: genetic factor in AIDS - more important than thought

hudgal1

10-21-2007 4:41 PM

425 views

tags:

aids, genes, immunology

hudgal1 says:

"A gene switches an otherwise benign infection to a lethal one." An interesting study on one of the worst plagues of our era.

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/8ab1842b-9e91-4ec4-bf32-2edd1834ebd6/C0A09FBA-D944-4823-93EB-F9A728DE3F7D/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.physorg.com/news112195799.html" href="http://www.physorg.com/news112195799.html" style="font-size: 11px;">www.physorg.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.physorg.com/news112195799.html"><H1>Genetic factor in AIDS progression is higher than thought: study</H1></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.physorg.com/news112195799.html"><DIV id="Preview"> 
 Variations in two key genes help determine how swiftly an individual infected with HIV progresses to AIDS, according to a study published on Sunday in the journal <I>Nature Immunology</I>.
</DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.physorg.com/news112195799.html"><DIV> 
The finding challenges quarter-century-old wisdom that what chiefly drives the advance to AIDS is "viral load," the amount of HIV in the blood, whose relentless rise bludgeons the <A class="iAs" classname="iAs" href="#" target="_blank" itxtdid="4164635">immune system</A>, the researchers say.
</DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.physorg.com/news112195799.html"><DIV>		
							Instead, they argue, the situation is more complex.
</DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.physorg.com/news112195799.html"><DIV>An individual's genetic profile can greatly affect replication of the human immunodeficiency virus (HIV) as well as the body's response to the intruder.
</DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.physorg.com/news112195799.html"><DIV>The interaction between the virus and the <A class="iAs" classname="iAs" href="#" target="_blank" itxtdid="2948423">immune</A> system switches "an otherwise benign infection to a lethal one," they say.
</DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.physorg.com/news112195799.html">n 2005, the same team that reports on Sunday, led by Sunil Ahuja of the University of Texas Health Science Center in San Antonio, found that the number of copies of the CCL3L1 genes is also a factor.</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/C0A09FBA-D944-4823-93EB-F9A728DE3F7D/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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