Cholesterol Drug Has No Benefit in Trial, Makers Say

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	Cholesterol Drug Has No Benefit in Trial, Makers Say

asphere

1-14-2008 5:06 PM

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tags:

cholesterol, drugs, vytorin, zetia, zocor

asphere says:

more in the article :
" In the United States, Zetia and Vytorin combined account for about 20 percent of the overall cholesterol-lowering market. More than 100 million prescriptions have been filled in the United States for Zetia and Vytorin since the Food and Drug Administration approved them in November 2002 and August 2004 respectively. Both drugs cost about $3 a day. "

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/e49c77a2-bad7-4168-9857-e5ff1209bf11/BBE97F2E-2FEB-4253-8CD8-1BA2EEE6A77D/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.nytimes.com/2008/01/14/business/14cnd-drug.html?ref=health" href="http://www.nytimes.com/2008/01/14/business/14cnd-drug.html?ref=health" style="font-size: 11px;">www.nytimes.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/01/14/business/14cnd-drug.html?ref=health"><P> A clinical trial of Zetia, a <A title="In-depth reference and news articles about Cholesterol." href="http://health.nytimes.com/health/guides/nutrition/cholesterol/overview.html?inline=nyt-classifier" linkindex="50">cholesterol</A>-lowering drug prescribed to about 1 million people a week, failed to show that the drug has any medical benefits, <A title="More information about Merck & Company" href="http://topics.nytimes.com/top/news/business/companies/merck_and_company/index.html?inline=nyt-org" linkindex="51" set="yes">Merck</A> and <A title="More information about Schering-Plough Corporation" href="http://topics.nytimes.com/top/news/business/companies/schering_plough_corporation/index.html?inline=nyt-org" linkindex="52" set="yes">Schering-Plough</A> said on Monday.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/01/14/business/14cnd-drug.html?ref=health"><P>The results will add to the growing concern over Zetia and Vytorin, a drug that combines Zetia with another cholesterol medicine in a single pill.  About 60 percent of patients who take Zetia do so in the form of Vytorin, which combines Zetia with the cholesterol drug <A title="Recent and archival health news about Zocor." href="http://topics.nytimes.com/top/news/health/diseasesconditionsandhealthtopics/zocor_drug/index.html?inline=nyt-classifier" linkindex="53">Zocor</A>.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/01/14/business/14cnd-drug.html?ref=health"><P>While Zetia lowers cholesterol by 15 percent to 20 percent in most patients, no trial has ever shown that it can reduce heart attacks and strokes — or even that it reduces the growth of the fatty plaques in arteries that can cause heart problems.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/01/14/business/14cnd-drug.html?ref=health"><P>This trial was designed to show that Zetia could reduce the growth of those plaques. Instead, the plaques actually grew almost twice as fast in patients taking Zetia along with Zocor than in those taking Zocor alone. </P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/BBE97F2E-2FEB-4253-8CD8-1BA2EEE6A77D/blog/" title="blog or email this clip"><img src="http://content7.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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