Gene Targeting | Clipmarks


	Gene Targeting

bullet11

10-28-2009 9:28 AM

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bullet11 says:

Gene Targeting- Generation of a KO mouse

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/7409c572-d816-4fd6-9b73-c82150045f06/B87C6966-4BCF-4E38-813D-A04032DE25AB/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://en.wikipedia.org/w/index.php?title=Gene_targeting&oldid=311672604" href="http://en.wikipedia.org/w/index.php?title=Gene_targeting&oldid=311672604" style="font-size: 11px;">en.wikipedia.org</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://en.wikipedia.org/w/index.php?title=Gene_targeting&oldid=311672604">To target genes in <A class="mw-redirect" title="Mus musculus" href="http://en.wikipedia.org/wiki/Mus_musculus">mice</A>, this construct is then inserted into mouse <A title="Embryonic stem cell" href="http://en.wikipedia.org/wiki/Embryonic_stem_cell">embryonic stem cells</A> in culture. After cells with the correct insertion have been selected, they can be used to contribute to a mouse's tissue via <A title="Embryo" href="http://en.wikipedia.org/wiki/Embryo">embryo</A> injection. Finally, <A title="Chimera (genetics)" href="http://en.wikipedia.org/wiki/Chimera_(genetics)">chimeric</A> mice where the modified cells made up the reproductive organs are selected for via <A title="Selective breeding" href="http://en.wikipedia.org/wiki/Selective_breeding">breeding</A>. After this step the entire body of the mouse is based on the previously selected embryonic stem cell.</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/B87C6966-4BCF-4E38-813D-A04032DE25AB/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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