Human skin cells hide circadian clock

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	Human skin cells hide circadian clock

wildcat

1-29-2008 7:11 AM

941 views

tags:

internal clock, skin cells

3 Comments |

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1-29-2008 7:50 AM

debbyski

WOW. Interesting.

1-30-2008 5:14 PM

BobbyRutan

I've always been an owl. How else are you gonna catch those fireflies?

1-30-2008 6:12 PM

debbyski

Ha,
I've been an early riser Bobby.

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/8107422a-2d2f-43a4-9383-5f4b2d65bbbd/96201414-6F68-4516-A006-FA69AC496066/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.newscientist.com/article/dn13231-human-skin-cells-hide-circadian-clock.html" href="http://www.newscientist.com/article/dn13231-human-skin-cells-hide-circadian-clock.html" style="font-size: 11px;">www.newscientist.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.newscientist.com/article/dn13231-human-skin-cells-hide-circadian-clock.html"><P>An internal clock hidden in human skin cells could reveal whether your body clock is out of sync with your lifestyle, say researchers.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.newscientist.com/article/dn13231-human-skin-cells-hide-circadian-clock.html"><P>Steven Brown of the University of Zurich in Switzerland and his colleagues knew that the brain’s circadian clock causes a gene called <I>Bmal1</I> to be more active in the body’s other cells during the daytime.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.newscientist.com/article/dn13231-human-skin-cells-hide-circadian-clock.html"><P>To find out how closely matched this activity was, they used a virus to equip skin cells taken from 11 early-rising people dubbed "larks" and 17 late-rising "owls" with a firefly gene that would produce a visible glow whenever <I>Bmal1</I> was active. “The result is light coming out of the cell in a 24-hour rhythm,” says Brown.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.newscientist.com/article/dn13231-human-skin-cells-hide-circadian-clock.html"><P>By monitoring the times when the cells glowed, they demonstrated that skin cells showed the same sleep-wake patterns as those reported in questionnaires by at least half the donors.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.newscientist.com/article/dn13231-human-skin-cells-hide-circadian-clock.html">“Knowing that skin clocks ‘tick’ in the same way as brain clocks provides a nice tool to address whether a person is likely to be an early or late riser,” </blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/96201414-6F68-4516-A006-FA69AC496066/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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