I think that the gov't is afraid that grapefruit may increase potency of methadone, or xanax, and the person that is being maintained on above might feel a sense of well being, rather than feeling anxious, paranoid, and afraid of this dangerous country full of killers, thieves that prey on old ladies, rape artists etc.
Yea, we have them all here in the US, as they are taught by this gov't to steal, take drugs, escape, and then forced to live in this incredibly crooked country. We take direction from thieves like George W Bush who steals the timberlies, sucks the very core (oil) from the earth, and then doesn't have the sense to fill in those holes (with a cement type substance) so that ear...

I think that the gov't is afraid that grapefruit may increase potency of methadone, or xanax, and the person that is being maintained on above might feel a sense of well being, rather than feeling anxious, paranoid, and afraid of this dangerous country full of killers, thieves that prey on old ladies, rape artists etc.
Yea, we have them all here in the US, as they are taught by this gov't to steal, take drugs, escape, and then forced to live in this incredibly crooked country. We take direction from thieves like George W Bush who steals the timberlies, sucks the very core (oil) from the earth, and then doesn't have the sense to fill in those holes (with a cement type substance) so that earthquakes and tremors won't come down on this oil glutton country. Need to drive, then play ball with Mother Earth.

For all those people who need to know.. read slow and multiple times.... Cytochrome P450 (CYP) 3A4 is the main CYP isozyme involved in methadone metabolism. We investigated the influence of grapefruit juice, which contains inhibitors of intestinal CYP3A, on the steady-state pharmacokinetics of methadone. METHODS: For 5 days, 8 patients undergoing methadone maintenance treatment received 200 mL water or grapefruit juice 30 minutes before and again together with their daily dose of methadone. Blood sampling for R-, S-, and R,S-methadone plasma determination was performed over a 24-hour period. CYP3A activity was determined by measuring the plasma 1'-hydroxymidazolam/midazolam ratio. RESULTS: A...

For all those people who need to know.. read slow and multiple times.... Cytochrome P450 (CYP) 3A4 is the main CYP isozyme involved in methadone metabolism. We investigated the influence of grapefruit juice, which contains inhibitors of intestinal CYP3A, on the steady-state pharmacokinetics of methadone. METHODS: For 5 days, 8 patients undergoing methadone maintenance treatment received 200 mL water or grapefruit juice 30 minutes before and again together with their daily dose of methadone. Blood sampling for R-, S-, and R,S-methadone plasma determination was performed over a 24-hour period. CYP3A activity was determined by measuring the plasma 1'-hydroxymidazolam/midazolam ratio. RESULTS: A decrease in the midazolam ratio was measured in all patients after grapefruit juice (mean +/- SD before grapefruit juice, 9.3 +/- 5.9; mean +/- SD after grapefruit juice, 3.9 +/- 1.2; P <.05). Grapefruit juice led to a mean 17% increase in the area under the curve extrapolated to 24 hours for both enantiomers of methadone (range, 3% to 29% [P <.005]; range, -4% to 37% [P <.05]; and range, 1% to 32% [P <.01]; for R-, S-, and R,S-methadone, respectively). A similar increase in peak level and decrease in apparent clearance were measured with grapefruit juice, whereas time to peak level, terminal half-life, and apparent volume during the terminal phase of R-, S-, and R,S-methadone were not affected by grapefruit juice. No symptom of overmedication was either detected by the clinical staff or reported by the patients. CONCLUSIONS: Grapefruit juice administration is associated with a modest increase in methadone bioavailability, which is not expected to endanger patients. However, it cannot be excluded that a much stronger effect may occur in some patients, and thus grapefruit juice intake is not recommended during methadone maintenance treatment, in particular in patients initiating such a treatment. and thats that... doesn't mean you cand do it on your own... just, to do it right dr

I have no idea where you were going with your comment Alexis2000. This is a topic about methadone and what may happen if it is taken along with white grapefruit juice. The next thing I know you're telling me that the govt doesn't want us to consume it while using methadone because they want us anxious and how nutcase W isn't filling holes (with a cement type substance) and earthquakes and tremors and drive with Mother Earth and play ball?!? W.T.F.!? Wow. FYI though. If our govt truly wanted us all to be anxious all of the time as you put it, then why are prescriptions of anti-anxiety and antidepressants drugs at record breaking numbers? If there were a conspiracy they would want us all to be...

I have no idea where you were going with your comment Alexis2000. This is a topic about methadone and what may happen if it is taken along with white grapefruit juice. The next thing I know you're telling me that the govt doesn't want us to consume it while using methadone because they want us anxious and how nutcase W isn't filling holes (with a cement type substance) and earthquakes and tremors and drive with Mother Earth and play ball?!? W.T.F.!? Wow. FYI though. If our govt truly wanted us all to be anxious all of the time as you put it, then why are prescriptions of anti-anxiety and antidepressants drugs at record breaking numbers? If there were a conspiracy they would want us all to be numb and toasty don'tcha think!? That way we wouldn't get all "uppity" whenever we felt like things weren't going right. Just my opinion. Thankfully, Gethighonmorphine provided us with a great post! Cheers GHOM!