Engineering bacteria to be used as biosensors


	Engineering bacteria to be used as biosensors

rj3sp

6-12-2008 1:32 PM

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tags:

bacteria, communication, cellular, biosensors, science, mit, michael laub

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/60e76d86-6cb6-42df-a19c-08dcc7cc379c/854696A0-4F79-45EB-B906-D0C31FB54D68/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.eurekalert.org/pub_releases/2008-06/miot-mru061108.php" href="http://www.eurekalert.org/pub_releases/2008-06/miot-mru061108.php" style="font-size: 11px;">www.eurekalert.org</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.eurekalert.org/pub_releases/2008-06/miot-mru061108.php"><H1 class="title">MIT researchers unravel bacteria communication pathways</H1></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.eurekalert.org/pub_releases/2008-06/miot-mru061108.php"><P>CAMBRIDGE, Mass. -- MIT researchers have figured out how bacteria ensure that they respond correctly to hundreds of incoming signals from their environment.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.eurekalert.org/pub_releases/2008-06/miot-mru061108.php"><P>The researchers also successfully rewired the cellular communications pathways that control those responses, raising the possibility of engineering bacteria that can serve as biosensors to detect chemical pollutants. The work is reported in the June 13 issue of <I>Cell</I>.</P></blockquote><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content6.clipmarks.com/images/clip-icon.gif" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://laublab.mit.edu/" href="http://laublab.mit.edu/" style="font-size: 11px;">laublab.mit.edu</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://laublab.mit.edu/"><div align="center"><img src="http://content7.clipmarks.com/blog_cache/laublab.mit.edu/img/51B972F0-BFF2-41F1-8886-A0CF27343DAC" alt="the laub lab" /></div></blockquote><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content8.clipmarks.com/images/clip-icon.gif" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://web.mit.edu/biology/www/facultyareas/facresearch/laub.html" href="http://web.mit.edu/biology/www/facultyareas/facresearch/laub.html" style="font-size: 11px;">web.mit.edu</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.mit.edu/biology/www/facultyareas/facresearch/laub.html"><div align="center"><img src="http://content9.clipmarks.com/blog_cache/web.mit.edu/img/1A6C8E0C-7AA0-44A7-987A-F899048536AC" alt="MIT Department of Biology" /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.mit.edu/biology/www/facultyareas/facresearch/laub.html"><div align="center"><img src="http://content6.clipmarks.com/blog_cache/web.mit.edu/img/6F493D54-728E-48C0-B34D-5FFB53546D45" alt="Angelika Amon photo" /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.mit.edu/biology/www/facultyareas/facresearch/laub.html"><P><STRONG>Specificity in signal transduction systems:</STRONG>
Another major focus in the lab is understanding how cells maintain the specificity of signaling systems. Given the highly related nature of the two-component signaling proteins in bacteria, how do cells maintain the insulation of different pathways? What prevents harmful cross-talk? How are signals integrated? We use both computational and experimental approaches to answer these questions.</P></blockquote><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content7.clipmarks.com/images/clip-icon.gif" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://laublab.mit.edu/research.html" href="http://laublab.mit.edu/research.html" style="font-size: 11px;">laublab.mit.edu</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://laublab.mit.edu/research.html"><div align="center"><img src="http://content8.clipmarks.com/blog_cache/laublab.mit.edu/img/A92F818A-BB7B-435A-9C79-4DE4CE20DB61" alt="specificity" /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://laublab.mit.edu/research.html"><div align="center"><img src="http://content9.clipmarks.com/blog_cache/laublab.mit.edu/img/A6A55E4A-8EE1-4CC6-878A-565B499BBE9F" alt="kinase profile" /></div></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/854696A0-4F79-45EB-B906-D0C31FB54D68/blog/" title="blog or email this clip"><img src="http://content6.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>