<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/a36093d7-d13c-4d02-851d-579d2e962962/72BEA538-795E-46A9-AB9A-8190076CD29A/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1" href="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1" style="font-size: 11px;">biology.plosjournals.org</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">Midbrain dopamine neurons play important roles in motor control, reward, addiction, attention, and cognition [<A href="#journal-pbio-0050325-b001">1</A>,<A href="#journal-pbio-0050325-b002">2</A>].</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">30% of the population will be over the age of 65 y around 2025 [<A href="#journal-pbio-0050325-b003">3</A>]</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">midbrain dopamine neurons are derived from the floor plate and that foxa2 plays a central role in specifying dopamine neurons.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">he initial deficit is asymmetric and preferentially affects dopamine neurons of the substantia nigra (SN) while leaving the ventral tegmental area (VTA) intact, a pattern of sensitivity also seen in Parkinson patients [<A href="#journal-pbio-0050325-b020">20</A>]</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">The <EM>foxa2</EM> Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1"><DIV id="hdr"> <DIV id="logo"><A title="PLoS Biology" href="http://biology.plosjournals.org"><SPAN>PLoS Biology</SPAN></A></DIV> <DIV id="tagline"><SPAN>A peer-reviewed, open-access journal published by the Public Library of Science</SPAN></DIV> <DIV id="db"> <UL> <LI class="last"><A class="alert" title="PLoS Users Login" href="http://www.plosjournals.org/perlserv/?request=myprofile">My Profile</A></LI> <li style="margin-left:16px;padding-left: 0px;"><A class="advanced" title="Advanced Search" href="http://biology.plosjournals.org/perlserv/?request=advanced-search&issn=1545-7885">Advanced Search</A></LI> <li style="margin-left:16px;padding-left: 0px;"><A class="rss" title="PLoS Biology RSS Feeds" href="http://journals.plos.org/plosbiology/rss_feeds.php">RSS</A></LI> </UL> <FORM action="http://biology.plosjournals.org/perlserv/#results" method="get" name="quicksearch" id="quicksearch"> <INPUT type="hidden" value="advanced-search" name="request" /> <INPUT type="hidden" value="1" name="row_start" /> <INPUT type="hidden" value="10" name="limit" /> <INPUT type="hidden" value="score" name="order" /> <INPUT type="hidden" value="1" name="search_fulltext" /> <INPUT type="hidden" value="1545-7885" name="issn" /> <INPUT type="hidden" value="1545-7885" name="jrn_issn" /> <INPUT type="hidden" value="any" name="anywhere_type" /> <FIELDSET> <LEGEND>Search PLoS Biology</LEGEND> <INPUT type="text" alt="Search PLoS Biology..." class="searchField" value="Search PLoS Biology..." name="anywhere" id="anywhere" /> <INPUT type="image" class="button" tabindex="3" alt="SEARCH" value="ftsearch" src="http://biology.plosjournals.org/images/jour_searchinput_btn.gif" /> </FIELDSET> </FORM> </DIV> </DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1"><H1>The <EM>foxa2</EM> Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age </H1></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/72BEA538-795E-46A9-AB9A-8190076CD29A/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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