Protein Identified-Involved In Causing Gum Disease, Osteoporosis, Arthritis


	Protein Identified-Involved In Causing Gum Disease, Osteoporosis, Arthritis

ncfootcare

9-1-2009 1:57 PM

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osteoporsis, arthritis

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9-5-2009 10:13 AM

ncfootcare

Bone is not a static structure, it is constantly breaking down and building back up again. Osteoclasts breakdown bone and osteoblasts build up bone, the action of these cells together is called bone remodeling. More on bone remodeling.

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/42d847ba-99e3-48bd-9a80-09089d9f4f34/69CD3336-E4E2-4C2F-A3A2-75ED87B5656D/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.medicalnewstoday.com/articles/162364.php" href="http://www.medicalnewstoday.com/articles/162364.php" style="font-size: 11px;">www.medicalnewstoday.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medicalnewstoday.com/articles/162364.php">Investigators at Hospital for Special Surgery, collaborating with researchers from other institutions, have contributed to the discovery that a gene called interferon regulator factor-8 (IRF-8) is involved in the development of diseases such as periodontitis (gum disease), rheumatoid <A title="What is Arthritis? What Causes Arthritis?" href="http://www.medicalnewstoday.com/articles/7621.php">arthritis</A> and <A title="What Is Osteoporosis? What Causes Osteoporosis?" href="http://www.medicalnewstoday.com/articles/155646.php">osteoporosis</A>. </blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medicalnewstoday.com/articles/162364.php"><DIV>
Specifically, the researchers discovered that downregulation of IRF-8 (meaning that the gene produces less IRF-8 protein) increases the production of cells called osteoclasts that are responsible for breaking down bone. An osteoblast is a type of cell that is responsible for forming bone and an osteoclast is a type of cell that breaks down bony tissue (bone resorption). In humans and animals, bone formation and bone resorption are closely coupled processes involved in the normal remodeling of bone. Enhanced development of osteoclasts, however, can create canals and cavities that are hallmarks of diseases such as periodontitis, osteoporosis and rheumatoid arthritis.
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