How Boys Become Boys (and Sometimes Girls)

arifsali

5-7-2008 5:14 PM

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/050b307b-eea2-405c-a2f7-1b349740fc2b/65650881-7CAC-4C34-87A0-945135017C1B/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.sciam.com/article.cfm?id=how-boys-become-boys-and&sc=rss" href="http://www.sciam.com/article.cfm?id=how-boys-become-boys-and&sc=rss" style="font-size: 11px;">www.sciam.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciam.com/article.cfm?id=how-boys-become-boys-and&sc=rss"><H2>New research explains how three proteins conspire to determine an embryo's sex</H2></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciam.com/article.cfm?id=how-boys-become-boys-and&sc=rss">In research that could give doctors a way to reassign sex in cases of unclear gender, scientists report this week that they have figured out why some children with genes that should make them boys are instead born as girls.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciam.com/article.cfm?id=how-boys-become-boys-and&sc=rss">  The study, <A href="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06944.html">published in <EM>Nature</EM></A>, explains why some embryos with X and Y chromosomes—which should be born as male—develop ovaries and eventually become girls.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciam.com/article.cfm?id=how-boys-become-boys-and&sc=rss">  The key is whether a gene called <EM>Sox</EM>9, involved in formation of the testes, is active. "There are a surprisingly large number of cases where this process goes wrong," says Robin Lovell-Badge, a biologist at London's MRC National Institute for Medical Research, who estimates that this phenomenon could effect up to 1 in every 20,000 genetic males. "Maybe one could treat some of these sex reversal or <A href="http://www.sciam.com/article.cfm?id=q-a-mixed-sex-biology">intersex cases</A> after birth by manipulating whether <EM>Sox9</EM> is active or not. This is all speculation but it's possible."</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciam.com/article.cfm?id=how-boys-become-boys-and&sc=rss"><div align="center"><img src="http://content8.clipmarks.com/blog_cache/www.sciam.com/img/C0BB9AAF-D7D5-4A27-8CB6-E68FA35BCDC5" alt="male female gender switch" /></div></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/65650881-7CAC-4C34-87A0-945135017C1B/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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