HIV's double hit on brain cells


	HIV's double hit on brain cells

breathenormally

8-16-2007 9:06 AM

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tags:

health, aids, hiv, brain, memory, learning, problems, proteins

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9-11-2007 6:56 PM

hiv-aids

Before I started AIDS medications, I know I was suffering from some kind of brain trama or HIV dementia. I still don't feel like me...

http://www.AIDSchat.org is where I hang out with other HIV positive people, come join if you are POZ too

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/351d5bee-e5b2-4aae-b480-422661dedca5/61BED0FE-D8C1-49FD-A9AA-212D06064DF4/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://news.bbc.co.uk/2/hi/health/6944255.stm" href="http://news.bbc.co.uk/2/hi/health/6944255.stm" style="font-size: 11px;">news.bbc.co.uk</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://news.bbc.co.uk/2/hi/health/6944255.stm">HIV can trigger learning and memory deficits by launching a double attack on the brain, research shows.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://news.bbc.co.uk/2/hi/health/6944255.stm"><table background="undefined" bgcolor=""><tr><TD class="sibtbg"><DIV>
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		<B>The HIV protein both causes brain injury and prevents its repair</B>
		<IMG width="23" vspace="0" height="13" border="0" align="right" alt="" src="http://newsimg.bbc.co.uk/nol/shared/img/v3/end_quote_rb.gif" /><BR clear="all" />	</DIV>
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	<DIV>Dr Marcus Kaul</DIV>
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</TD></tr></table></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://news.bbc.co.uk/2/hi/health/6944255.stm"><P>
<FONT size="2">Part of the problem is that anti-HIV drugs find it tough to enter the brain.
</FONT></P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://news.bbc.co.uk/2/hi/health/6944255.stm"><FONT size="2">In the latest study, they showed that gp120 also slows production of new brain cells in the hippocampus, a brain region central to learning and memory.
</FONT></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://news.bbc.co.uk/2/hi/health/6944255.stm"><FONT size="2">The researchers had already shown that a protein called gp120, which is found on HIV's outer coating, can kill off brain cells by disrupting their internal chemistry.
</FONT></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://news.bbc.co.uk/2/hi/health/6944255.stm"><P>
<FONT size="2">Keith Alcorn, senior editor of the HIV information service NAM, said: "The discovery that HIV affects stem cell proliferation in the brain is bound to add to concerns that people with HIV doing well on antiretroviral therapy may nevertheless face a higher risk of dementia in years to come.
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<FONT size="2">"The HIV protein both causes brain injury and prevents its repair."
</FONT></P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/61BED0FE-D8C1-49FD-A9AA-212D06064DF4/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>