成人幹細胞實驗可救回疾病的肌肉

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	成人幹細胞實驗可救回疾病的肌肉

tgkuo

12-15-2007 10:17 PM

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tags:

muscle

tgkuo says:

老鼠實驗顯示，取自人類罹患肌萎縮症的肌細胞前驅之成人幹細胞，DMD CD133+，內有突變Dystrophin基因，加以改正後，再植回體肉，可顯著的改善老鼠肌萎縮症的肌肉型態、功能及Dystrophin基因的表現。

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</DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medicalnewstoday.com/articles/91668.php"><DIV>
The researchers then used a sophisticated genetic technique to repair the mutated dystrophin gene in the isolated DMD CD133+ cells so that dystrophin synthesis was restored. Importantly, intramuscular or intra-arterial delivery of the genetically corrected muscle cell progenitors resulted in significant recovery of muscle morphology, function, and dystrophin expression in a mouse model of muscular dystrophy.
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