The Chaos Inside a Cancer Cell


	The Chaos Inside a Cancer Cell

Silkweaver

12-27-2008 1:09 PM

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tags:

genetics, dna, cancer

Silkweaver says:

One of the rearrangements disrupts a gene called RAD51C which is involved in mending serious chromosome breaks, those in which both strands in the DNA are disrupted. The impairment of double strand break repair could be a major cause of all the other rearrangements, the researchers suggest.

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/729ac22f-e0b3-4358-927a-ad9c8fb0fa5f/52F19F1A-E5C0-4ED0-8FBA-50D35F6D481B/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss" href="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss" style="font-size: 11px;">www.nytimes.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss"><div align="center"><img src="http://content7.clipmarks.com/blog_cache/www.nytimes.com/img/36E94F64-CC41-4546-90AB-8A6784E30AA9" alt="" /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss">A striking feature of many cancer cells is that the DNA in their chromosomes is all jumbled up.  Chunks of DNA containing one or more genes have been ripped out of their chromosome and reinserted in a different place. Other lengths of DNA have been transferred to a different chromosome altogether.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss">These rearrangements may degrade the cell's regulatory systems, especially when a rearrangement cuts a gene in half, or separates it from the regions of DNA that control its activity.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss">Researchers led by Oliver A. Hampton and Aleksandar Milosavljevic at the Baylor College of Medicine in Houston have now compared the genome of a type of breast cancer cell with that of normal cells. They find 157 rearrangements, they report in the current issue of Genome Research.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss">The graphic summarizes their results.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss">The lines in blue, in the third ring, show internal rearrangements</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.nytimes.com/2008/12/25/science/25visual.html?_r=1&partner=rss&emc=rss">The red lines, in the bull's eye, designate switches of DNA from one chromosome to another</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/52F19F1A-E5C0-4ED0-8FBA-50D35F6D481B/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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