Most likely it is first of its kind; however, Canada had Little Mosque as a major hit last year.

the writers’ credit that “Aliens” is instead fresh, funny and charming in a tart, sardonic way, one of the best sendups of adolescent angst since “The Wonder Years” and “Malcolm in the Middle”

If it's even close to "Malcolm in the Middle" then it must do well. Good clip

Canada had Little Mosque as a major hit last year.

Thought of that myself

Although you did say first American.

It wasn't that bad, here is the link.