Jekyll and Hyde gene in brain cancer


	Jekyll and Hyde gene in brain cancer

Antonio Rambaldi

2-11-2008 10:14 PM

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/80b0d20e-6d31-4bbf-98cb-cae5e4180da8/2CB1D8DB-13CB-44D0-8B6B-E69465EE48E5/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://web.med.harvard.edu/sites/RELEASES/html/020608Bonni.html" href="http://web.med.harvard.edu/sites/RELEASES/html/020608Bonni.html" style="font-size: 11px;">web.med.harvard.edu</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.med.harvard.edu/sites/RELEASES/html/020608Bonni.html"><STRONG>Gene plays “Jekyll and Hyde” in brain cancer</STRONG></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.med.harvard.edu/sites/RELEASES/html/020608Bonni.html"><EM><STRONG>FINDINGS:</STRONG>
Researchers have found that a particular gene is central to the brain cancer glioblastoma and will either fight the tumor or, conversely, help the tumor advance, depending on the tumor’s genetic makeup. </EM></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.med.harvard.edu/sites/RELEASES/html/020608Bonni.html"><P>One approach focuses on a gene called STAT3. In several tumors, STAT3 takes
	    the role of an oncogene, that is, a gene whose normal functions are derailed
	    and, as a result, becomes a driving force in a tumor’s development.
	    Clearly then, blocking STAT3 would deal a major blow to such tumors.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.med.harvard.edu/sites/RELEASES/html/020608Bonni.html"><P>While glioblastoma tends to be uncommon, STAT3 has also been implicated
	    in prostate and breast cancers, so these results may translate to other
	    types of tumors as well. </P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/2CB1D8DB-13CB-44D0-8B6B-E69465EE48E5/blog/" title="blog or email this clip"><img src="http://content6.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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