Second genetic link to weight and obesity found

arifsali

5-6-2008 12:10 PM

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/0461028a-b1ce-4e54-9b18-50893db362ae/22811113-A009-4483-B6CB-05B31C7D9D1C/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.ox.ac.uk/media/news_stories/2008/080505.html" href="http://www.ox.ac.uk/media/news_stories/2008/080505.html" style="font-size: 11px;">www.ox.ac.uk</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.ox.ac.uk/media/news_stories/2008/080505.html"><STRONG>New genetic variants that influence fat mass, weight and risk of obesity have been uncovered via an international investigation led by Oxford and Cambridge researchers.</STRONG></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.ox.ac.uk/media/news_stories/2008/080505.html">A study of 90,000 people from seven countries found that
these variants map close to a gene called <EM>MC4R.</EM>
Mutations in this gene are the most common genetic cause of severe familial
obesity and it is already known that rare, highly disruptive variants in the <EM>MC4R</EM> gene are responsible for very
severe, genetic forms of obesity. The collaboration has now uncovered more
common variants that affect more people.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.ox.ac.uk/media/news_stories/2008/080505.html"><P class="MsoNormal">The team, whose research is published in <EM>Nature Genetics</EM>, found that two copies
of these genetic variants resulted in an average increase in weight of about
1.5 kg.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.ox.ac.uk/media/news_stories/2008/080505.html"><div align="center"><img src="http://content7.clipmarks.com/blog_cache/www.ox.ac.uk/img/E34F7AD8-C5AB-451D-B347-6F3B6832256E" alt="Bacchus by Flemish painter Peter Paul Rubens (June 28, 1577 – May 30, 1640)." /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.ox.ac.uk/media/news_stories/2008/080505.html"><DIV>It's not just genes though - lifestyle contributes to body mass, too</DIV></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/22811113-A009-4483-B6CB-05B31C7D9D1C/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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