<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/697e688e-10aa-4209-9e84-43dee025f1e3/12D435F1-85D3-4793-81DB-5A351D3DBB45/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/" href="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/" style="font-size: 11px;">consults.blogs.nytimes.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/">The experiments were designed to test the hypothesis that memories are stored by the action of a specific molecule— PKMzeta. You should know that the notion that a specific molecule stores memory goes completely against the grain of how most neuroscientists have thought about long-term memory for decades. Most neuroscientists thought that memories were stored by anatomical changes in the brain, such as new synapses, not by specific molecules. That is why our results showing a very rapid disruption of long-term memories, first published in Science in 2006, were so striking. </blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/">Interestingly, ZIP does not affect short-term memory, or once the drug is gone, the formation of new long-term memories in the same brain region.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://consults.blogs.nytimes.com/2009/04/13/memory-erasing/">PKMzeta is bound up in the neurofibrillary tangles that are found in the brains of patients with Alzheimer’s Disease. This is likely to alter the function of PKMzeta and may contribute to the memory loss characteristic of that disorder.</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/12D435F1-85D3-4793-81DB-5A351D3DBB45/blog/" title="blog or email this clip"><img src="http://content7.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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