Connexin 43 as a signaling platform for increasing 3D regeneration of tissue

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	Connexin 43 as a signaling platform for increasing 3D regeneration of tissue

mdpool

8-12-2009 4:48 PM

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/c9839f42-ed74-4dd8-84b5-00e587f81864/0ED1AC74-A9B2-4620-AC0E-2A63B493C4D2/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.pnas.org/content/106/32/13219" href="http://www.pnas.org/content/106/32/13219" style="font-size: 11px;">www.pnas.org</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.pnas.org/content/106/32/13219">In bone marrow stromal cells (BMSC), GJIC and osteogenic
                     differentiation were compromised in 3D cultures relative to 2D monolayers and in the core of 3D cultures relative to the surface.
                     Overexpression of connexin 43 (Cx43) via transduction of BMSCs with a lentivirus overcame this problem, enhancing both the
                     magnitude and spatial distribution of GJIC and osteogenic differentiation markers throughout 3D constructs. Transplantation
                     of cells overexpressing Cx43 resulted in an increased volume fraction and spatial uniformity of bone in vivo, relative to
                     nontransduced BMSCs. Increased GJIC also enhanced the effect of a potent osteoinductive agent (BMP-7), suggesting a synergism
                     between the soluble factor and GJIC.</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/0ED1AC74-A9B2-4620-AC0E-2A63B493C4D2/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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