The Nanoimpeller -- Controlled Drug Release in Cancer Cells


	The Nanoimpeller -- Controlled Drug Release in Cancer Cells

rj3sp

4-2-2008 4:02 AM

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tags:

nanotechnology

rj3sp says:

About a light-powered nanomachine that operates inside a living cell, A development that has strong implications for cancer treatment.

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/f9375277-b3d2-43ed-a4b5-95ecd23821c6/0BDFBAB3-7CB7-480F-AB18-ACD012CFE5A8/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.medgadget.com/archives/2008/04/light_activated_drug_nanotransporter.html" href="http://www.medgadget.com/archives/2008/04/light_activated_drug_nanotransporter.html" style="font-size: 11px;">www.medgadget.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medgadget.com/archives/2008/04/light_activated_drug_nanotransporter.html"><DIV><A title="" href="http://www.medgadget.com"><IMG width="460" height="123" border="0" src="http://www.medgadget.com/images/logo.gif" alt="" /></A></DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medgadget.com/archives/2008/04/light_activated_drug_nanotransporter.html"><H1><A title="Light Activated Drug Nanotransporters" href="http://www.medgadget.com/archives/2008/04/light_activated_drug_nanotransporter.html ">Light Activated Drug Nanotransporters</A></H1></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medgadget.com/archives/2008/04/light_activated_drug_nanotransporter.html"><div align="center"><img src="http://content7.clipmarks.com/blog_cache/www.medgadget.com/img/8D7D8F39-8C78-4CC6-9001-AC458408E838" alt="" /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medgadget.com/archives/2008/04/light_activated_drug_nanotransporter.html">Using clever technology and special chemicals, UCLA scientists were able to create unique transport intracellular nanoparticles, motorized by 'nanoimpellers', that can be manually activated to release their cargo with a switch of a light, potentially allowing for precise targeting of drugs directly to the tumor. </blockquote><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content8.clipmarks.com/images/clip-icon.gif" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.cnsi.ucla.edu/news/item?item_id=465298" href="http://www.cnsi.ucla.edu/news/item?item_id=465298" style="font-size: 11px;">www.cnsi.ucla.edu</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.cnsi.ucla.edu/news/item?item_id=465298">
To achieve this, the UCLA researchers used mesoporous silica nanoparticles and coated the interiors of the pores with azobenzene, a chemical that can oscillate between two different conformations upon light exposure.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.cnsi.ucla.edu/news/item?item_id=465298">
The pores of the particles can be loaded with cargo molecules, such as dyes or anticancer drugs. In response to light exposure, a wagging motion occurs, causing the cargo molecules to escape from the pores and attack the cell. Confocal microscopic images showed that the impeller operation can be regulated precisely by the intensity of the light, the excitation time and the specific wavelength.</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/0BDFBAB3-7CB7-480F-AB18-ACD012CFE5A8/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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