Our Molecular Age vs. Our Chronological Age


	Our Molecular Age vs. Our Chronological Age

darkduskx

6-19-2009 12:22 AM

226 views

darkduskx says:

It's official, tobacco use and physical inactivity, not really BMI, ages you. Time to quit smoking and start exercising more.

The more interesting question:

Could counteracting p16INK4a be the real fountain of youth?

Did Juan Ponce de León need a genetics degree, not a ship and armed men?

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/97e411a0-1968-4d5e-b135-be1e0c28c3b2/098FC3F0-20D5-4577-8139-76AB3307A0CB/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.med.unc.edu/www/news/test-detects-molecular-marker-of-aging-in-humans" href="http://www.med.unc.edu/www/news/test-detects-molecular-marker-of-aging-in-humans" style="font-size: 11px;">www.med.unc.edu</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.med.unc.edu/www/news/test-detects-molecular-marker-of-aging-in-humans">Tuesday, June 16, 2009 — A team of UNC researchers has proven that a key protein called p16INK4a is present in human blood and is strongly correlated both with chronological age and with certain behaviors such as tobacco use and physical inactivity, which are known to accelerate the aging process</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.med.unc.edu/www/news/test-detects-molecular-marker-of-aging-in-humans">as cells and tissues age, the expression of a key protein, called p16<SUP>INK4a</SUP>, dramatically increases in most mammalian organs</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.med.unc.edu/www/news/test-detects-molecular-marker-of-aging-in-humans">p16<SUP>INK4a</SUP> is a tumor suppressor protein, cancer researchers are interested in its role in cellular aging and cancer prevention</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.med.unc.edu/www/news/test-detects-molecular-marker-of-aging-in-humans">This is a major step toward a practical tool to clinically determine a person’s actual molecular, as opposed to just their chronological age</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.med.unc.edu/www/news/test-detects-molecular-marker-of-aging-in-humans">We found a very weak correlation between the biomarker and obesity – as measured by body mass index (BMI) – despite other data suggesting that caloric restriction slows aging.  The data suggest the possibility that reduced exercise may actually be worse with regard to molecular age than a higher BMI</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/098FC3F0-20D5-4577-8139-76AB3307A0CB/blog/" title="blog or email this clip"><img src="http://content7.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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